Oxyresveratrol Tetra Acetate
Products : Oxyresveratrol Tetra Acetate
Structure :
Chemical Name : 2.4.3'.5'-Tetraacetyl oxyresveratrol
Molecular Formula : C22H20O8
Molecular Weight : 412.4
Synonyms : Oxyresveratrol tetra acetate
Physical Properties : White crystalline solid.
Solubility : Soluble in Isopropyl alcohol Methanol, Ethanol and Acetone.
Chemical Reaction : Characteristic reactions of stilbene esters
Bio Activity : Extremely effective Tyrosinase inhibitor
Skin is a barrier of our body with lipophilic membrane. Therefore skin absorption of chemicals is determined by its physicochemical properties.
Lipophilicity (Soluble in fat/lipid) is one of the important factors that affect the skin permeation process.
Melanocytes (melanin synthesizing cells) and keratinocytes exists in epidermis, the outermost layer of the skin. Lipophilic (oil soluble) compounds penetrate deeper in the skin layers.
Oxyresveratrol tetra acetate is more lipophilic than Oxyresveratrol. The compound (OTA)show better permeability and bioavailability on skin. The limitations of chemical stability poor solubility and low bio availability of the parent compound has been overcome with OTA. CLINICAL trial with OTA formulations establish the same.
OTA Is considered as the prodrug of oxyresveratrol,Once inside the skin cell it decomposes in presence of enzyme , releasing oxyresveratrol imparting better activity in the cells.
Tyrosinase inhibitory activity Of OTA (Oxyresveratrol tetra acetate) slightly more than Oxyresveratrol. Moreover OTA is not susceptible to oxidative discoloration in formulation and is less cytotoxic.
Recommended dosage :
Skin lightening formulation – 0.20 to 0.40 gms/100 gm.
Specifications
| Properties | Specification |
|---|---|
| Colour and appearance | White crystalline needles |
| Solubility | Freely soluble in, Methanol, Ethanol and Acetone |
| Solubility in water | Water in soluble |
| Ash content | Less than 0.5% |
| Moisture content | Less than 1% |
| Melting Point | 141-143 C |
| Heavy metals | Less than 20 ppm |
| Assay | By HPLC, Not less than 98% |
| Method of analysis | AOAC Official methods of analysis 1990 |
Reference
-
Archives of Dermatological Research, July 2014, Volume 306, Issue 5, pp 475–487Jiaa Park, Joon Heum Park, Hwa-Jin Suh, In Chul Lee, Jaesook Koh, Yong Chool Boo Effects of resveratrol, oxyresveratrol, and their acetylated derivatives on cellular melanogenesis
click here.. -
WO 2014116022 , Jul 31, 2014Kyungpook National University Industry-Academic Cooperation Foundation Use of resveratrol derivative for skin whitening
click here..
Overview
Products : Oxyresveratrol Tetra Acetate
Structure :
Chemical Name : 2.4.3'.5'-Tetraacetyl oxyresveratrol
Molecular Formula : C22H20O8
Molecular Weight : 412.4
Synonyms : Oxyresveratrol tetra acetate
Physical Properties : White crystalline solid.
Solubility : Soluble in Isopropyl alcohol Methanol, Ethanol and Acetone.
Chemical Reaction : Characteristic reactions of stilbene esters
Bio Activity : Extremely effective Tyrosinase inhibitor
Skin is a barrier of our body with lipophilic membrane. Therefore skin absorption of chemicals is determined by its physicochemical properties.
Lipophilicity (Soluble in fat/lipid) is one of the important factors that affect the skin permeation process.
Melanocytes (melanin synthesizing cells) and keratinocytes exists in epidermis, the outermost layer of the skin. Lipophilic (oil soluble) compounds penetrate deeper in the skin layers.
Oxyresveratrol tetra acetate is more lipophilic than Oxyresveratrol. The compound (OTA)show better permeability and bioavailability on skin. The limitations of chemical stability poor solubility and low bio availability of the parent compound has been overcome with OTA. CLINICAL trial with OTA formulations establish the same.
OTA Is considered as the prodrug of oxyresveratrol,Once inside the skin cell it decomposes in presence of enzyme , releasing oxyresveratrol imparting better activity in the cells.
Tyrosinase inhibitory activity Of OTA (Oxyresveratrol tetra acetate) slightly more than Oxyresveratrol. Moreover OTA is not susceptible to oxidative discoloration in formulation and is less cytotoxic.
Recommended dosage :
Skin lightening formulation – 0.20 to 0.40 gms/100 gm.
Specification
| Properties | Specification |
|---|---|
| Colour and appearance | White crystalline needles |
| Solubility | Freely soluble in, Methanol, Ethanol and Acetone |
| Solubility in water | Water in soluble |
| Ash content | Less than 0.5% |
| Moisture content | Less than 1% |
| Melting Point | 141-143 C |
| Heavy metals | Less than 20 ppm |
| Assy | By HPLC, Not less than 98% |
| Method of analysis | AOAC Official methods of analysis 1990 |
Reference
-
Archives of Dermatological Research, July 2014, Volume 306, Issue 5, pp 475–487Jiaa Park, Joon Heum Park, Hwa-Jin Suh, In Chul Lee, Jaesook Koh, Yong Chool Boo Effects of resveratrol, oxyresveratrol, and their acetylated derivatives on cellular melanogenesis
click here.. -
WO 2014116022 , Jul 31, 2014Kyungpook National University Industry-Academic Cooperation Foundation Use of resveratrol derivative for skin whitening
click here..