Oxyresveratrol Tetra Acetate
Advanced Lipophilic Skin Delivery System
Oxyresveratrol Tetra Acetate
Skin is a barrier to our body with amphipathic membrane. Therefore skin absorption of chemicals is determined by its physicochemical properties.
Lipophilicity (Soluble in fat/lipid) is one of the important factors that affect the skin permeation process.
Melanocytes (melanin synthesizing cells) and keratinocytes exist
in epidermis, the outermost layer of the skin. Lipophilic (oil soluble) compounds penetrate deeper in the skin layers.
Oxyresveratrol tetra acetate is more lipophilic than Oxyresveratrol. The compound (OTA) shows better permeability and bioavailability on skin. The limitations of chemical stability poor solubility and low bioavailability of the parent compound has been overcome with OTA. Clinical trial with OTA formulations establishes the same.
OTA is considered as the prodrug of oxyresveratrol, once inside the skin cell it decomposes in presence of an enzyme, releasing oxyresveratrol imparting better activity in the cells.
Tyrosinase inhibitory activity of OTA (Oxyresveratrol tetra acetate) is slightly more than Oxyresveratrol. Moreover OTA is not susceptible to oxidative discoloration in formulations and is less cytotoxic.
Recommended dosage :
Skin lightening formulation – 0.20 to 0.40 g/100 gm.
| Product | Oxyresveratrol Tetra Acetate |
| Chemical Name | 2,4,3',5'-Tetraacetyl oxyresveratrol |
| Molecular Formula | C22H20O8 |
| Molecular Weight | 412.4 |
| Synonyms | Oxyresveratrol tetra acetate |
| Physical Properties | White crystalline solid |
| Solubility | Isopropyl alcohol, Methanol, Ethanol, and Acetone |
| Chemical Reaction | Characteristic reactions of stilbene esters |
| Bio Activity | Extremely effective tyrosinase inhibitor |